Search results for "Galactosylated polymeric micelles"

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Galactosylated micelles for a ribavirin prodrug targeting to hepatocytes.

2013

Polymeric micelles potentially able to carry to hepatocytes a ribavirin (RBV) prodrug, exploiting the presence of carbohydrate receptors, that is, ASGPR, were prepared starting from a galactosylated polylactide-polyaminoacid conjugate. This latter was obtained by chemical reaction of α,β-poly(N-2-hydroxyethyl) (2-aminoethylcarbamate)-dl-aspartamide (PHEA-EDA) with polylactic acid (PLA), and subsequent reaction with lactose, obtaining PHEA-EDA-PLA-GAL copolymer. To enhance the entrapment into obtained nanostructures, a hydrophobic RBV prodrug, that is, RBV tripalmitate, was synthesized and its capability to release RBV in the presence of an adequate enzymatic activity was demonstrated. Liver…

Magnetic Resonance SpectroscopyPolymers and PlasticsBioengineeringMicelleAntiviral AgentsBiomaterialschemistry.chemical_compoundNon-competitive inhibitionPolylactic acidRibavirinSpectroscopy Fourier Transform InfraredMaterials ChemistryCopolymerOrganic chemistryHumansProdrugsMicellesChemistrytechnology industry and agricultureGalactoseHep G2 CellsProdrugCarbohydrateCombinatorial chemistryIn vitroLiverSettore CHIM/09 - Farmaceutico Tecnologico ApplicativoGalactosylated polymeric micelles hepatic cell-targeted carriers active targeting ribavirin tripalmitate hepatitis C.ConjugateBiomacromolecules
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